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Celebrex is a type of nonsteroidal anti-inflammatory drug (NSAIDs). Celebrex works by reducing substances that cause inflammation, pain, and fever in the body. Celebrex is used to reduce pain, inflammation, and stiffness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celebrex is also used to reduce the number of adenomatous colorectal polyps in familial adenomatous polyposis (FAP), to treat acute pain, and to treat pain associated with menstruation.