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Metformin regulates blood glucose levels to tackle age-related diabetes and lower cholesterol Metformin lowers the levels of gucose (sugar) in blood in three different ways. First, it reduces the amount of glucose produced by your liver; second, it reduces the amount of glucose absorbed from food through your stomach; and third, it improves the effectiveness of insulin in the body in reducing glucose already in the blood. This triple action makes Metformin ideal for treating type II diabetes.