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Sertraline (ZOLOFT) treats depression, obsessive-compulsive disorder, panic attacks, posttraumatic stress disorder and social anxiety disorder. Sertraline can also relieve the symptoms of premenstrual dysphoric disorder, which includes mood swings, irritability, bloating, and breast tenderness. Sertraline is a type of medications called selective serotonin reuptake inhibitors (SSRIs) and works by increasing the amounts of serotonin, one of the natural substance in the brain thatis known is control mental balance.